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The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

✍ Scribed by Vetrie, D.


Book ID
109784769
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
88 KB
Volume
364
Category
Article
ISSN
0028-0836

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## Mutations in the Bruton's tyrosine kinase (BTK ) gene are responsible for X-linked Agammaglobulinemia (XLA), an immunodeficiency caused by a block in B cell differentiation. Non Isotopic RNAse Cleavage Assay (NIRCA), followed by sequencing was used to screen for BTK mutations in 11 Italian XLA p

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## Communicated by David Ginsburg Bruton's tyrosine kinase (Btk) has been identified as the protein responsible for the primary immunodeficiency X-linked agammaglobulinemia (XLA) and has been described as a new member of Srcrelated cytoplasmic protein tyrosine kinases. We have recently characteriz