## Mutations in the Bruton's tyrosine kinase (BTK ) gene are responsible for X-linked Agammaglobulinemia (XLA), an immunodeficiency caused by a block in B cell differentiation. Non Isotopic RNAse Cleavage Assay (NIRCA), followed by sequencing was used to screen for BTK mutations in 11 Italian XLA p
β¦ LIBER β¦
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases
β Scribed by Vetrie, D.
- Book ID
- 109784769
- Publisher
- Nature Publishing Group
- Year
- 1993
- Tongue
- English
- Weight
- 88 KB
- Volume
- 364
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/364362a0
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## Communicated by David Ginsburg Bruton's tyrosine kinase (Btk) has been identified as the protein responsible for the primary immunodeficiency X-linked agammaglobulinemia (XLA) and has been described as a new member of Srcrelated cytoplasmic protein tyrosine kinases. We have recently characteriz