The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
✍ Scribed by Schmitz, Gerd; Bodzioch, Marek; Orsó, Evelyn; Klucken, Jochen; Langmann, Thomas; Böttcher, Alfred; Diederich, Wendy; Drobnik, Wolfgang; Barlage, Stefan; Büchler, Christa; Porsch-Özcürümez, Mustafa; Kaminski, Wolfgang E.; Hahmann, Harry W.; Oette, Kurt; Rothe, Gregor; Aslanidis, Charalampos; Lackner, Karl J.
- Book ID
- 109486156
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 507 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/11914
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## Genes have a major role in the control of high-density lipoprotein (HDL) cholesterol (HDL-C) levels. Here we have identified two Tangier disease (TD) families, confirmed 9q31 linkage and refined the disease locus to a limited genomic region containing the gene encoding the ATP-binding cassette