๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

The Fusion of Control Analysis and Temporal Analysis of Metabolic Systems

โœ Scribed by John S. Easterby

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
169 KB
Volume
182
Category
Article
ISSN
0022-5193

No coin nor oath required. For personal study only.

โœฆ Synopsis

Metabolic control analysis and the study of the transient response of metabolic systems had coincident births in 1973. They developed along parallel lines until in 1989/90 their complete fusion occurred. It was evident that the control of the transient response of metabolism could be described in terms of general control properties, such as the flux and concentration control coefficients and elasticities. Consequently, it is possible to define temporal control coefficients which relate to the lifetimes of individual metabolite pools or to the total system temporal response. These control coefficients are readily expressed in terms of the flux and concentration control coefficients. Therefore, to analyse the control of metabolism is also to analyse its temporal response.

๐Ÿ“œ SIMILAR VOLUMES

Temporal analysis of metabolic systems a
Temporal analysis of metabolic systems and its application to metabolite channelling
โœ John S. Easterby ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 864 KB

## Abstract When a metabolic system undergoes a transition between steady states, the lag or transition time of the system is determined by the aggregated lifetimes of the metabolite pools. This allows the transition time, and hence the temporal responsiveness of the system, to be estimated from a

The Mathematics of Metabolic Control Ana
The Mathematics of Metabolic Control Analysis Revisited
โœ Diana Visser; Joseph J. Heijnen ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 126 KB

In this minireview, several different approaches to derivation of the theorems and relationships of Metabolic Control Analysis (MCA) are discussed and an alternative approach is presented. This new approach consists of solving the steady-state mass balances for the intracellular metabolites using li

Control Analysis in Terms of Generalized
Control Analysis in Terms of Generalized Variables Characterizing Metabolic Systems
โœ Stefan Schuster ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 244 KB

Metabolic Control Analysis had originally been devised to quantify the effects of changes in enzyme concentrations on steady-state fluxes and metabolite concentrations. In many situations, fluxes and concentrations are not the only relevant variables. A formalism is presented by which the control of

Optimization-based metabolic control ana
Optimization-based metabolic control analysis
โœ Korkut Uygun; Basak Uygun; Howard W. T. Matthew; Yinlun Huang ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› American Institute of Chemical Engineers ๐ŸŒ English โš– 318 KB
Metabolic Control Analysis: Separable Ma
Metabolic Control Analysis: Separable Matrices and Interdependence of Control Coefficients
โœ Ludwig Elsner; Christoph Giersch ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 324 KB

A central quantity for the analysis of the interdependence of control coefficients is the Jacobian H of the pathway. For a simple metabolic chain, H is known to be tridiagonal. Its inverse H-1, which is required to calculate control coefficients, is semi-separable. A semi-separable nxn matrix (aij)