The function of vestigial in Drosophila wing development: How are tissue-specific responses to signalling pathways specified?
✍ Scribed by Jose F. de Celis
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 106 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
✦ Synopsis
The activities of conserved signal transduction pathways are central to the development of Drosophila wings, legs, and eyes. Yet, all these structures have characteristic morphologies, suggesting that additional factors provide organspecific information. One excellent candidate for such a function is Vestigial, which activity promotes the formation of wings. The biochemical function of Vestigial is unknown, however, since no homologies with other proteins have been identified. Two recent reports show that Vestigial interacts with the transcription factor Scalloped, (1,2) forming an active complex that binds to specific DNA sequences and regulates gene expression in cooperation with several signalling pathways. (3) These results illustrate how tissue-specific transcription factors cooperate with general signalling pathways to regulate gene expression in a tissuespecific manner.