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The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

✍ Scribed by Sharpe, Arlene H; Wherry, E John; Ahmed, Rafi; Freeman, Gordon J

Book ID
109923346
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
386 KB
Volume
8
Category
Article
ISSN
1529-2908

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The programmed death 1/programmed death ligand 1 inhibitory pathway is up-regulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis
✍ Amalia P. Raptopoulou; George Bertsias; Dimitrios Makrygiannakis; Panagiotis Ver πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 607 KB

## Abstract ## Objective T cells play a major role in the pathogenesis of rheumatoid arthritis (RA). The programmed death 1 (PD‐1)/programmed death ligand 1 (PDL‐1) pathway is involved in peripheral tolerance through inhibition of T cells at the level of synovial tissue. The aim of this study was