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The function of neuropeptide secretin in early postnatal neurogenesis and autism-like phenotypes in mice

✍ Scribed by Ichiko Nishijima


Book ID
116778704
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
50 KB
Volume
71
Category
Article
ISSN
0168-0102

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## Abstract Insulin‐like growth factor‐1 (IGF‐1) is essential to hippocampal neurogenesis and the neuronal response to hypoxia/ischemia injury. IGF (IGF‐1 and ‐2) signaling is mediated primarily by the type 1 IGF receptor (IGF‐1R) and modulated by six high‐affinity binding proteins (IGFBP) and the