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The function of human NK cells is enhanced by β-glucan, a ligand of CR3 (CD11b/CD18)

✍ Scribed by Livia Di Renzo; Eitan Yefenof; Eva Klein

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
374 KB
Volume
21
Category
Article
ISSN
0014-2980

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✦ Synopsis

f5-Glucan potentiates NK activity

The function of human NK cells is enhanced P-glucan, a ligand of CR3 (CDllb/CDlS)* 1755 bY Cells responsible for the natural killer (NK) effect in the human blood can be collected in the low-density lymphocyte subset and the majority of them express CR3. In addition to the iC3b binding site the CR3 molecules possess an epitope which binds P-glucan. Ligands of this site can deliver activation signals to CR3-carrying monocytes and neutrophils.We found that the function of NK cells was also potentiated by preincubation with P-glucan.The treatment increased the proportion of target-binding lymphocytes and of the damaged target cells in the conjugates. The monoclonal antibody OKM-1, directed to the b-glucan-binding site of CR3, abrogated this effect. Another CR3-reactive monoclonal antibody, M522, known to activate monocytes and neutrophils, enhanced the NK function.

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Induction of cell-associated interleukin 1 through stimulation of the adhesion-promoting proteins LFA-1 (CD11a/CD18) and CR3 (CD11b/CD18) of human monocytes
✍ Christine Couturier; Nicole Haeffner-cavaillon; Laurence Weiss; Elisabeth Fische 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 666 KB

## Abstract Serum‐free culture of human monocytes in the presence of monoclonal antibodies to the LFA‐1 α chain (CD11a), CR3 α chain (CD11b) or β chain (CD18) bound to Sepharose induced the dose‐dependent production of cell‐associated interleukin (IL) 1 activity and of IL 1α and IL 1β antigens, but