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The function of human intercellular adhesion molecule-1 (ICAM-1) in the generation of an immune response

โœ Scribed by Graeme J. Dougherty; Sarah Murdoch; Nancy Hogg

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
802 KB
Volume
18
Category
Article
ISSN
0014-2980

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โœฆ Synopsis

Monoclonal antibody RR 111 directed against the putative LFA-1 ligand molecule intracellular adhesion molecule-1 (ICAM-1) was found to inhibit the T cell proliferative response to the antigen PPD. Interestingly, the percentage of unstimulated monocytes which expressed ICAM-1 on their surface appeared to vary greatly from person to person although the majority of monocytes did express high levels of ICAM-1 within their cytoplasm and surface expression could be rapidly induced on most cells by adherence to fibronectin. Resting T cells showed no evidence of surface or cytoplasmic ICAM-1 although expression was induced both within the cell and on the membrane as a result of activation with phytohemagglutinin or a combination of OKT3 and phorbol12J3-dibutyrate. The significance of these findings with respect to the function of monocyte and T cell in the generation of an immune response is discussed.

Recently, it has been proposed that a 90-kDa cell surface glycoprotein, designated intercellular adhesion molecule-1

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