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The frequent and conserved DR3-B8-A1 extended haplotype confers less diabetes risk than other DR3 haplotypes

โœ Scribed by E. E. Baschal; T. A. Aly; J. M. Jasinski; A. K. Steck; K. N. Johnson; J. A. Noble; H. A. Erlich; G. S. Eisenbarth; Diabetes Genetics Consortium


Book ID
109044769
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
185 KB
Volume
11
Category
Article
ISSN
1462-8902

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Homozygous typing cells from 13 normal HLA-A1, B8, Dw3, DR3 and five normal HLA-A26, Bw38, Dw10, DR4 individuals were typed for the following markers: HLA-SB, MB, MT; complement proteins BF, C2, C4A, C4B; and GLO. Ninety-one percent of A1, B8, Dw3, DR3 homozygous individuals (HI) tested were homozyg