The frequency and distribution of thiopurine S-methyltransferase alleles in south Iranian population
β Scribed by Maryam Moini; Fatemeh Ghaderi; Mohamad Mehdi Sagheb; Ali Reza Tavasolli; Negar Azarpira; Masumeh Darai; Bita Geramizadeh
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 270 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0301-4851
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Background. Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation (inactivation) of mercaptopurine, azathioprine, and thioguanine, and exhibits genetic variation. About 11% of Caucasians have intermediate TPMT activity because of heterozygosity, and about 1 in 300 inherits TPMT deficienc
## Allele frequency distribution for the variable number of tandem repeat locus DlOS28 in Tamil Nadu (South India) population Allele frequencies were determined in unrelated individuals of Tamil speaking population from the Madras City (Tamil Nadu, South India) area for the polymorphic DNA locus D