In order to more easily study the absorption, excretion, and distribution patterns of 7-chloro-1 -(cyclopropylmethyl)-5-phenyl-1 H-1,4-benzodiazepin-
The fragmentation of 5-phenyl-1,4-benzodiazepin-2-ones. Mechanism for the formation of [M H]+
β Scribed by Wolfgang Benz; Floie M. Vane; Uwe Rapp
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 517 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1076-5174
No coin nor oath required. For personal study only.
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## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbonβ14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^Cβbenzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des
The mass spectrometric behaviour of six 2a,4-disubstituted 5-benzoyl-2-chloro-2a,3,4,5-tetrahydroazeto[1,2-a][1,5]benzodiazepin-1(2H)-ones has been studied with the aid of mass-analysed ion kinetic energy spectrometry and accurate mass measurements under electron impact ionization. All compounds sho