Polymorphisms in the regulatory region of the human apolipoprotein E gene (gene, APOE; protein, apoE) have been implicated in Alzheimer's disease. Here we describe in detail the advantages of a simple method for haplotype analysis of this region (at -491 and -427 bases relative to the transcription
The fourth apolipoprotein E haplotype found in the Yoruba of Ibadan
โ Scribed by Jill R. Murrell; Brandon M. Price; Olusegun Baiyewu; Oye Gureje; Mark Deeg; Hugh Hendrie; Adesola Ogunniyi; Kathleen Hall
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 40 KB
- Volume
- 141B
- Category
- Article
- ISSN
- 1552-4841
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it M/inchen Summary. Serum lipid concentrations of patients with familial defective apolipoprotein B-100 (FDB) show a high interindividual variability although the underlying defect is caused by a single point mutation. On the other hand, several genetic factors modulating serum cholesterol levels a
The E4 allele of apolipoprotein E (apoE4) has previously been associated with symptomatic gallstone disease. The aim of this study was to determine if apoE4 is associated with the development of gallbladder sludge and/or stones during pregnancy. We conducted a nested case-control study based on an o