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The formation of the triple helix in a mixed solution of (Pro-Pro-Gly)n and (Pro-Pro-Gly)n′. A model of molecular size recognition

✍ Scribed by Yukio Suezaki; Nobuhiro Gō

Publisher
Wiley (John Wiley & Sons)
Year
1974
Tongue
English
Weight
465 KB
Volume
13
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

A theoretical analysis is given of the triple‐helix–random‐coil transition in a mixed solution of poly(Pro‐Pro‐Gly)~n~ with two different but defined degrees of polymerization n and n′. Because of the highly cooperative nature of this helix–coil transition, each polypeptide chain tends to form a triple helix with other polypeptide chains with the same degree of polymerization (size recognition). Occurrence of triple helices consisting of polypeptide chains with different degrees of polymerization (error in recognition) is studied in detail as a function of the cooperativity, and n and n′. Implication of this analysis for molecular recognition in general is discussed.

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