It has been proposed that the chiral inversion of the 2-arylpropionic acids is due to the stereospecific formation of the ( -)-R-profenyl-CoA thioesters which are putative intermediates in the inversion. Accordingly, amino acid conjugation, for which the CoA thioesters are obligate intermediates, sh
The formation of peptides from glycine thioesters
✍ Scribed by Arthur L. Weber; Leslie E. Orgel
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 444 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0022-2844
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A one-pot procedure for the synthesis of thioesters from primary amines is reported. Polyamides containing one or more primary amines were prepared by solid-phase synthesis and reacted with thiolane-2,5-dione followed by alkylation with benzyl bromide to produce the target thioesters in good yield.
## Abstract The preferred conformation of three __N__^α^‐acetylated Aib/Iva host/guest pentapeptide esters and their __N__^α^‐benzyloxycarbonylated synthetic precursors, prepared by solution methods and fully characterized, were examined in chloroform solution using FT‐IR absorption and ^1^H‐NMR an