Generation of two isomers with the same
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Naoyoshi Chino; Shigeru Kubo; Mikiya Miyazato; Masamitsu Nakazato; Kenji Kangawa
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Article
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1996
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Springer Netherlands
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English
โ 473 KB
In a two-step selective disulfide-bond-forming reaction of human uroguanylin, a 16-residue peptide with two intramolecular disulfide bonds, two compounds (I and II) were formed, which could be detected by RP-HPLC after the second disulfide-bond-forming reaction and were isolated as single entities.