The formation of both nucleoside anomers in the reaction of a crystalline 1,2-cis-glycosyl halide with a heavy metal salt of a purine

✍ Scribed by G.T. Rogers; T.L.V. Ulbricht

• Book ID: 104249500
• Publisher: Elsevier Science
• Year: 1968
• Tongue: French
• Weight: 161 KB
• Volume: 9
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)98881-1

✦ Synopsis

Ruler regarding the anomeric configuration of the nucleoeidee produced by the reaction of glycosyl halides with the heavy metal ealts of purine b'8ses were originally formulated by B8ker.l In the case of sugar derivatives with 8 participating group (such as -OIlOR) at position 2, both 1,2-a and a-glyconyl halides give 8 1.2-a nucleoside 8s product, by single and double S$ reactions respectively, as shown below for ribose or glucose2 (for vhich 1.2-a -8, 3,2-a -S).

a 8