The Formation of Biodegradable Polymeric Micelles from Newly Synthesized Poly(aspartic acid)-block-Polylactide AB-Type Diblock Copolymers
✍ Scribed by Hidetoshi Arimura; Yuichi Ohya; Tatsuro Ouchi
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 121 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1022-1336
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✦ Synopsis
Abstract
Summary: A poly(aspartic acid)‐block‐polylactide (PAsp‐block‐PLA) diblock copolymer was synthesized through the polymerization of β‐benzyl‐L‐aspartate‐N‐carboxyanhydride [Asp(OBzl)‐NCA] with amino‐terminating polylactide (NH~2~‐PLA) as a macroinitiator. The chain length of the PAsp segment could be easily controlled by changing the monomer/initiator ratio. Dynamic light scattering measurements of PAsp‐block‐PLA aqueous solutions revealed the formation of polymeric micelles. Changes in the micelles as a function of pH were investigated.
The structure and formation of micelles of the poly(aspartic acid)‐block‐polylactide (PAsp‐block‐PLA) diblock copolymers synthesized here.
imageThe structure and formation of micelles of the poly(aspartic acid)‐block‐polylactide (PAsp‐block‐PLA) diblock copolymers synthesized here.