The formation of active oxygen species following activation of 1-naphthol, 1,2- and 1,4-naphthoquinone by rat liver microsomes
โ Scribed by Paul J. Thornalley; Mary d'Arcy Doherty; Martyn T. Smith; Joe V. Bannister; Gerald M. Cohen
- Book ID
- 113136831
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 687 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0009-2797
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๐ SIMILAR VOLUMES
The short-term toxicity of 2-hydroxy-1,4-naphthoquinone (lawsone) and 2-methyl-1,4-naphthoquinone (menadione) has been compared in rats. 2-Methyl-I ,4-naphthoquinone has been shown previously to cause haemolytic anaemia in animals, and this was confirmed in the present experiment. 2-Hydroxy-l,4-nap
## Abstract Naphthoquinone derivatives are under investigation as potential therapeutic agents. Some such compounds are known, however, to be toxic to both animals and humans. Many naphthoquinone derivatives are haemolytic agents, while others cause necrosis of tubular epithelial cells. In the pres