## Abstract A comprehensive protocol is presented for the in vivo evaluation of soft tissue foreign body reactions to surgical implants. A number of methods of evaluation and quantitation of the tissue reaction to implants are presented and discussed. A strong plea is made for semiβquantitation of
The foreign body reaction: A chronic inflammatory response
β Scribed by Coleman, D. L. ;King, R. N. ;Andrade, J. D.
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- English
- Weight
- 698 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0021-9304
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
A brief discussion is presented of some of the problems and artifacts inherent in the testing of soft tissue reactions to artificial implants. The process of inflammation and wound healing is presented. The various factors affecting the foreign body reaction (chemical, mechanical, geometrical, and others) are discussed. The cellular components of the foreign body reaction are described and the sequential cellular changes that may occur as a result of implanting an artificial device are examined. The foreign body reaction should be considered as a chronic inflammatory response.
π SIMILAR VOLUMES
## Abstract Multinucleated giant cells (GCs) are often observed in the foreign body reaction against implanted materials. The __in vivo__ function of GCs in this inflammatory process remains to be elucidated. GCs degrade collagen implants in rats and may also orchestrate the inflammatory process vi
## Abstract The role(s) of T lymphocytes in the foreign body response has not been thoroughly elucidated. Lymphocytes are known to augment macrophage adhesion and fusion __in vitro__. Furthermore, T lymphocytes are a possible source of the cytokines, ILβ4 and ILβ13, which induce macrophage fusion.