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The folding funnel landscape for the peptide met-enkephalin

✍ Scribed by Ulrich H.E. Hansmann; Yuko Okamoto; Jose N. Onuchic

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 477 KB
Volume: 34
Category: Article
ISSN: 0887-3585
DOI: 10.1002/(sici)1097-0134(19990301)34:4<472::aid-prot7>3.0.co;2-x

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✦ Synopsis

We study the free energy landscape of the small peptide Met-enkephalin. Our data were obtained from a generalized-ensemble Monte Carlo simulation taking the interactions among all atoms into account. We show that the free energy landscape resembles that of a funnel, indicating that this peptide is a good folder. Our work demonstrates that the energy landscape picture and folding concept, developed in the context of simplified protein models, can also be used to describe the folding in more realistic models.

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