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The First Total Synthesis of 2,3,6-Tribromo-4,5-dihydroxybenzyl Methyl Ether (TDB) and Its Antioxidant Activity.

✍ Scribed by Jae-Kon Kim; Jung Hyun Noh; Sungeun Lee; Jae Sue Choi; Hongsuk Suh; Hae Young Chung; Yeong-Ok Song; Won Chul Choi


Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
33
Category
Article
ISSN
0931-7597

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## Abstract 3,4‐Dibromo‐5‐[2‐bromo‐3,4‐dihydroxy‐6‐(methoxymethyl)benzyl]benzene‐1,2‐diol (**2**), a natural product, has been synthesized for the first time starting from (3‐bromo‐4,5‐dimethoxyphenyl)methanol (**5**) in five steps and with an overall yield of 34%. The reaction of some methoxymethy