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The first successful intermolecular Heck reaction of Baylis–Hillman adducts: synthesis of β-aryl substituted Baylis–Hillman adducts

✍ Scribed by Jeong Mi Kim; Ko Hoon Kim; Taek Hyeon Kim; Jae Nyoung Kim


Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
122 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis


The first successful intermolecular Heck reaction between Baylis-Hillman adducts and aryl iodides was achieved under the conditions comprising Pd(OAc) 2 /n-Bu 4 NBr/KOAc in CH 3 CN.


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A simple and convenient methodology for the sterenselective construction of 2--benzyl substituted trisubstituted olefins via sulfuric acid catalyzed Friedel-Cmfls reaction of benzene with Baylis-Hillman adducts is described.