✦ LIBER ✦
The first stereo selective total synthesis of (3R),(5R)-5-hydroxy-de-O-methyllasiodiplodin and its epimer via an RCM protocol
✍ Scribed by J.S. Yadav; Saibal Das; J. Satyanarayana Reddy; N. Thrimurtulu; A.R. Prasad
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 314 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The first total synthesis of (3R),(5R)-5-hydroxy-de-O-methyllasiodiplodin and its epimer is reported from malic acid. The adopted approach is highly convergent and stereoselective. The strategy utilizes syn selective reduction and ring-closing metathesis as key steps.