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The first pass metabolism of nifedipine in man.

✍ Scribed by DG Waller; AG Renwick; BS Gruchy; CF George


Book ID
117943616
Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
437 KB
Volume
18
Category
Article
ISSN
0306-5251

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The peroral (po) bioavailability of nifedipine is reported to range from about 45 to 58% in the rat; this compares favourably to human beings. The metabolism of nifedipine is similar in rats and humans (oxidation of the dihydropyridine ring), with the liver believed to be solely responsible for the

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