EXTRAHEPATIC FIRST-PASS METABOLISM OF NI
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JOHN S. GRUNDY; LISE A. ELIOT; ROBERT T. FOSTER
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Article
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1997
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John Wiley and Sons
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English
β 170 KB
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The peroral (po) bioavailability of nifedipine is reported to range from about 45 to 58% in the rat; this compares favourably to human beings. The metabolism of nifedipine is similar in rats and humans (oxidation of the dihydropyridine ring), with the liver believed to be solely responsible for the