Nonallelic homologous recombination (NAHR) is the major mechanism underlying recurrent genomic rearrangements, including the large deletions at 17q11.2 that cause neurofibromatosis type 1 (NF1). Here, we identify a novel NAHR hotspot, responsible for type-3 NF1 deletions that span 1.0 Mb. Breakpoint
✦ LIBER ✦
The first human mitotic nonallelic homologous recombination hotspot associated with genetic disease
✍ Scribed by Chen, Jian-Min
- Book ID
- 118759342
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 65 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1059-7794
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