The first generation of candidate HIV-1 vaccines can induce antibodies able to neutralize primary isolates in assays with extended incubation phases

Epitopes corresponding to the envelope g

Epitopes corresponding to the envelope genetic subtype are present on the surface of free virions of HIV-1 group M primary isolates and can be detected in neutralization assays with extended incubation phases

✍ David Davis; Helen Donners; Betty Willems; Tine Vermoesen; Leo Heyndrickx; Rober 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 117 KB

## Abstract The hypothesis is that there are neutralizing epitopes on the surface of free virions of human immunodeficiency virus type 1 (HIV‐1) that correspond to the genetic subtype of the envelope glycoprotein. Assays with extended incubation and reduced absorption phases are required to demonst