The first fatal 2,6-di-isopropylphenol (propofol) poisoning in Singapore: a case report
✍ Scribed by T.C. Chao; D.S.T. Lo; P.P.S. Chui; T.H. Koh
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 500 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0379-0738
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✦ Synopsis
The propofol levels in the blood and tissues of a 37-year-old Chinese male suspected of having fatally self-administered an intravenous dose of 1600 mg of propofol (12.3-15.4 times the dose required for the induction of anaesthesia) were determined by headspace gas chromatography. The blood (femoral), liver, kidney and brain propofol levels were 2.5 micrograms/ml, 22 micrograms/g, 3.6 micrograms/g and 11.3 micrograms/g, respectively. The blood propofol level in the present case is 11.4 times and the liver propofol level is 15.7 times that of the first propofol overdose reported in the literature.