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The first enzymatic method for C–18F bond formation: the synthesis of 5′-[18F]-fluoro-5′-deoxyadenosine for imaging with PET

✍ Scribed by Laurent Martarello; Christoph Schaffrath; Hai Deng; Antony D Gee; Andrew Lockhart; David O'Hagan

Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
118 KB
Volume
46
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The use of the key enzyme involved in carbon–fluorine bond formation in Streptomyces cattleya catalysing the formation of 5′‐fluoro‐5′‐deoxyadenosine (5′‐FDA) from fluoride ion and S‐adenosyl‐l‐methionine (SAM) was explored for its potential application in fluorine‐18 labelling of the adenosine derivative. Enzymatic radiolabelling of [^18^F]‐5′‐FDA was successfully carried out starting from SAM and [^18^F]HF when the concentration of the enzyme preparation was increased from sub‐mg/ml values to mg/ml values. The purity of the enzyme had no measurable effect on the radiochemical yield of the reaction and the radiochemical purity of [^18^F]‐5′‐FDA. Copyright © 2003 John Wiley & Sons, Ltd.

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