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The first Bischler–Napieralski cyclization in a room temperature ionic liquid

✍ Scribed by Zaher M.A. Judeh; Chi Bun Ching; Jie Bu; Adam McCluskey

Book ID
104251415
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
73 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

We have demonstrated the use of the room temperature ionic liquid, 1-butyl-3-methylimidazoliumhexafluorophosphate ([bmim]PF 6 ), as an environmentally benign solvent for the preparation of isoquinoline derivatives through Bischler-Napieralski cyclization under mild conditions with excellent purity and yields. The role of HF as a catalyst in the reaction was also investigated.

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Pictet—Spengler Cyclization in Room Temp
Pictet—Spengler Cyclization in Room Temperature Ionic Liquid: A Convenient Access to Tetrahydro β-Carbolines.
✍ M. Muthukrishnan; Shivaji V. More; Dinesh R. Garud; C. V. Ramana; R. R. Joshi; R 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 17 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Pictet-spengler cyclization in room temp
Pictet-spengler cyclization in room temperature ionic liquid: A convenient access to tetrahydro β-carbolines
✍ M. Muthukrishnan; Shivaji V. More; Dinesh R. Garud; C. V. Ramana; R. R. Joshi; R 📂 Article 📅 2006 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 359 KB 👁 1 views

## Abstract magnified image 1,2,3,4‐Tetrahydro‐β‐carbolines have been synthesized in moderate to good yields in short reaction time using the ionic liquid [bbim] BF~4~ as reaction medium and promoter. There was no need for the use of an additional catalyst normally employed in Pictet‐Spengler cond