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The First Asymmetric Synthesis of α-Sulfanylphosphonates

✍ Scribed by Marchand, Patrice; Gulea, Mihaela; Masson, Serge; Saquet, Monique; Collignon, Noël


Book ID
125941597
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
43 KB
Volume
2
Category
Article
ISSN
1523-7060

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Synthesis of chiral, nonracemic α-sulfan
✍ Mihaela Gulea; Friedrich Hammerschmidt; Patrice Marchand; Serge Masson; Violeta 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 165 KB

Optically active a-sulfanylphosphonates and the corresponding methyl sulfides were prepared in three steps starting from chiral, nonracemic (ee 93-97%) a-hydroxyphosphonates obtained by enzymatic resolution. Reaction conditions for the reduction of racemisation-prone substrates were found to preserv