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The first asymmetric carbonylation of 1-(6′-methoxy-2′-naphthyl)ethanol to the methyl ester of (S)-naproxen

✍ Scribed by Bao-Han Xie; Chun-Gu Xia; Shi-Jie Lu; Ke-Jun Chen; Yuan Kou; Yuan-Qi Yin

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
150 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

I-(6'-Methoxy-2'-naphthyl)ethanol is asymmetrically carbonylated to the methyl ester of (,~-naproxen in a PdCI2-CuCI2-DDPPI (DDPPI: 1,4:3,6-dianhydro-2,5-dideoxy-2,5-bis(diphenylphosphino)-L-iditol) catalytic system with a chemical yield of 90% and an optical yield of 81% e.e.. The reaction was carried out in ethyl methyl ketone under 100°C and 8 MPa of CO for 24-48h.

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