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The First Aminoacylase-Catalyzed Enantioselective Synthesis of Aromatic β-Amino Acids.

✍ Scribed by Harald Groeger; Harald Trauthwein; Stefan Buchholz; Karlheinz Drauz; Christiane Sacherer; Sylvie Godfrin; Helge Werner


Publisher
John Wiley and Sons
Year
2004
Weight
18 KB
Volume
35
Category
Article
ISSN
0931-7597

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✍ Andreas Krebs; Verena Ludwig; José Pfizer; Gerd Dürner; Michael W. Göbel 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 207 KB

We present two complementary methods for the stereoselective synthesis of non-natural alpha-amino acids with aromatic or heteroaromatic side chains. One approach is based on the chemical transformation of methionine, whereas the other applies the stereoselective Myers alkylation of glycine. The resu