The fine structure of HNK-1 (Leu7) positive cells

✍ Scribed by G. C. Manara; G. Panfilis; C. Ferrari; A. Bonati; R. Scandroglio

• Book ID: 104786112
• Publisher: Springer
• Year: 1984
• Tongue: English
• Weight: 871 KB
• Volume: 81
• Category: Article
• ISSN: 1432-119X
• DOI: 10.1007/bf00490109

✦ Synopsis

The ultrastructural characteristics of HNK-1 (Leu7) positive cells, visualized with a peroxidase labelled anti-mouse IgM serum, were analysed. Our investigation demonstrates: 1) the majority of Leu7 positive cells has a low nuclear/cytoplasmic ratio (N/C), an irregular outline, a well developed smooth endoplasmic reticulum, parallel tubular arrays (PTA) and electron dense granules; 2) the minority of Leu7 positive cells has a high N/C, regular profiles and lacks electron dense granules. The presence of two distinct ultrastructural patterns within Leu7 positive cells may represent: 1) the expression of subsequent stages of cell differentiation; 2) two distinct Leu7 positive cell subpopulations.