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The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B

✍ Scribed by Kay Huebner; Piotr Hadaczek; Zurab Siprashvili; Teresa Druck; Carlo M. Croce

Book ID
114222932
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
175 KB
Volume
1332
Category
Article
ISSN
0304-419X

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Precise localization of the FHIT gene to
Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines
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Chromosomal or allelic losses at 3p14 are common in a variety of human tumors, including those of the lung, breast, kidney, and head and neck. This suggests the existence of a tumor suppressor gene in this band. A promising candidate is the recently cloned FHIT gene, which spans the common fragile s

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Common chromosomal fragile sites are unstable genomic loci susceptible to breakage, rearrangement, and are highly recombinogenic. Frequent alterations at these loci in tumor cells led to the hypothesis that they may contribute to cancer development. The two most common chromosomal fragile sites FRA1