Fatty acid synthase inhibition with Orli
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Marco A. Carvalho; Karina G. Zecchin; Fabiana Seguin; DΓ©bora C. Bastos; Michelle
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Article
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2008
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John Wiley and Sons
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French
β 635 KB
## Abstract Fatty acid synthase (FASN) is the enzyme responsible for the endogenous synthesis of the saturated fatty acid palmitate. In contrast to most normal cells, malignant cells depend on FASN activity for growth and survival. In fact, FASN is overexpressed in a variety of human cancers includ