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The fatty acid synthase inhibitor orlistat reduces tumor growth and lymph node metastasis in an orthotopic murine model of oral squamous cell carcinoma


Book ID
119336285
Publisher
Elsevier
Year
2012
Tongue
English
Weight
60 KB
Volume
114
Category
Article
ISSN
2212-4403

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## Abstract Fatty acid synthase (FASN) is the enzyme responsible for the endogenous synthesis of the saturated fatty acid palmitate. In contrast to most normal cells, malignant cells depend on FASN activity for growth and survival. In fact, FASN is overexpressed in a variety of human cancers includ