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The fate of transplanted cells in mouse blastocystsin vitro

✍ Scribed by Moustafa, Laila A. ;Brinster, R. L.

Publisher
John Wiley and Sons
Year
1972
Tongue
English
Weight
667 KB
Volume
181
Category
Article
ISSN
0022-104X

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✦ Synopsis

Abstract

Four‐day synchronous blastocyst donor cells and 8‐ and 12‐day asynchronous embryonic cells were transplanted adjacent to and within the inner cell mass of four‐day recipient blastocysts. Virtually all recipient blastocysts tolerated micrurgical procedures and regained their β€œnormal” size and shape after four hours of incubation. About 3% of all recipient blastocysts exhibited rejected cells.

The nuclei of the transplanted cells, labeled with tritiated thymidine, appeared to be present in various phases of the cell cycle 20 hours after transplant. After 40 hours in culture, the number of labeled cells was significantly greater than the number of cells transplanted in both the synchronous and asynchronous transplants. The present study shows for the first time that chronologically older cells can divide in a younger embryo and suggests that they participate in the structure of the recipient embryo.

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