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The fate of heterologous CD4+ T cells during Leishmania donovani infection

✍ Scribed by Rosalind Polley; Soombul Zubairi; Paul M. Kaye

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
181 KB
Volume
35
Category
Article
ISSN
0014-2980

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## Abstract To study the role of IL‐12 as a third signal for T‐cell activation and differentiation __in vivo__, direct IL‐12 signaling to CD8^+^ T cells was analyzed in bacterial and viral infections using the P14 T‐cell adoptive transfer model with CD8^+^ T cells that lack the IL‐12 receptor. Resu