𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The fate of duplicated genes: loss or new function?

✍ Scribed by Wagner, Andreas (author)

Publisher
John Wiley and Sons Inc.
Year
1998
Tongue
English
Weight
55 KB
Volume
20
Category
Article
ISSN
0265-9247

No coin nor oath required. For personal study only.

✦ Synopsis

Gene duplication events are important sources of novel gene functions. However, more often than not, a duplicate gene may lose its function and become a pseudogene. What is the relative frequency of these two scenarios: functional divergence versus gene loss? Given that most non-neutral mutations are deleterious, gene loss should be far more frequent than divergence. However, a recent empirical study (1) suggests that about 50% of all gene duplications will lead to functional divergence. The study infers the frequency of functional divergence from the size distribution of gene families produced by two successive genome duplications early in vertebrate evolution. Reasons for this unexpectedly high frequency of functional divergence are discussed.

πŸ“œ SIMILAR VOLUMES

The fate of duplicated major histocompat
The fate of duplicated major histocompatibility complex class Ia genes in a dodecaploid amphibian, Xenopus ruwenzoriensis
✍ BΓ©nΓ©dicte Sammut; Anne Marcuz; Louis Du Pasquier πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 364 KB

The dodecaploid anuran amphibian Xenopus ruwenzoriensis represents the only polyploid species of Xenopus in which the full silencing of the extra copies of the major histocompatibility complex (MHC) has not occurred. Xenopus ruwenzoriensis is a recent polyploid that has evolved within one of the two

The Characterization of Two New Clusters
The Characterization of Two New Clusters of Duplicated Genes Suggests a β€˜Lego’ Organization of the YeastSaccharomyces cerevisiae Chromosomes
✍ Feuermann, M.; de Montigny, J.; Potier, S.; Souciet, J.-L. πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 129 KB

The systematic sequencing of 42,485 bp of yeast chromosome VII (nucleotides 377948 to 420432) has revealed the presence of 27 putative open reading frames (ORFs) coding for proteins of at least 100 amino acids. The degree of redundancy observed is elevated since five of the 27 ORFs are duplications

Restricted distribution of loss-of-funct
Restricted distribution of loss-of-function mutations within the LMX1B genes of nail-patella syndrome patients
✍ Mark V. Clough; Jeanette D. Hamlington; Iain McIntosh πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 277 KB

Nail-patella syndrome (NPS) is a pleiotropic condition characterized by dysplasia of the nails, hypoplasia of the patellae, elbow dysplasia, and progressive kidney disease. The syndrome is inherited in an autosomal dominant manner and has been shown to result from mutations in the LIMhomeodomain enc