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The fanconi anemia C protein is a transcriptional regulator of Dickkopf-1

✍ Scribed by Masi, Delphine; Mazon, Mélody; Huard, Caroline; Carreau, Madeleine

Book ID
125824455
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
52 KB
Volume
42
Category
Article
ISSN
0301-472X

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Fanconi anemia (FA), a genetic disorder predisposing to aplastic anemia and cancer, is characterized by hypersensitivity to DNA-damaging agents and oxidative stress. Five of the cloned FA proteins (FANCA, FANCC, FANCE, FANCF, FANCG) appear to be involved in a common functional pathway that is requir