Alzheimer dementia caused by a novel mut
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J. Theuns; E. Marjaux; M. Vandenbulcke; K. Van Laere; S. Kumar-Singh; G. Bormans
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Article
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2006
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John Wiley and Sons
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English
β 313 KB
Since the first report showing that Alzheimer disease (AD) might be caused by mutations in the amyloid precursor protein gene (APP), 20 different missense mutations have been reported. The majority of early-onset AD mutations alter processing of APP increasing relative levels of Abeta42 peptide, eit