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The familial Alzheimer's disease mutations cause the accumulation of amyloidogenic C-terminal fragments of APP


Book ID
123386009
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
176 KB
Volume
13
Category
Article
ISSN
0197-4580

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Since the first report showing that Alzheimer disease (AD) might be caused by mutations in the amyloid precursor protein gene (APP), 20 different missense mutations have been reported. The majority of early-onset AD mutations alter processing of APP increasing relative levels of Abeta42 peptide, eit