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The facilitative role of epithelial barrier disruption in successful gene transfer to the colon

โœ Scribed by Vallance, B.A.; Radojevic, N.; Barbara, G.; Galeazzi, F.; Graham, F.L.; Gauldie, J.; Collins, S.M.

Book ID
123466672
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
174 KB
Volume
114
Category
Article
ISSN
0016-5085

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## Background: In the IL-10 gene-deficient mouse model, development of intestinal inflammation is associated with a defect in epithelial barrier integrity that is thought to allow sufficient passage of bacteria or bacterial antigens to initiate a mucosal immune response. Microbial monoassociation