Regioselective Synthesis of N-Substitute
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Rafael MartΔ±Μnez; Hugo A. JimΓ©nez-VΓ‘zquez; JoaquΔ±Μn Tamariz
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Article
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2000
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Elsevier Science
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French
β 172 KB
AbstractΓN-Substituted 4-methylene-2-isoxazolidinones 9aΒ±9e have been prepared from the tandem condensation of isocyanates 3 with a-ketol 7. In a more polar solvent (DMF) the same reaction led to stereoisomeric alcohols 11 and 12, which could be transformed to the thermodynamically more stable isome