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The extracellular matrix in oral squamous cell carcinoma: Friend or foe?

โœ Scribed by Amy F. Ziober; Erica M. Falls; Barry L. Ziober

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
216 KB
Volume
28
Category
Article
ISSN
1043-3074

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โœฆ Synopsis

Abstract

Oral squamous cell carcinoma is a disfiguring, highly invasive and metastatic cancer. Despite advances in detection and therapy, many patients will continue to face a poor prognosis. It is well established that the predominate factor determining overall survival in patients with oral squamous cell carcinoma is lymph node involvement. Tumor growth and progression to invasive cancer requires tumor cell interactions with the extracellular matrix. An understanding of how the extracellular matrix influences tumor development and invasion is fundamental in the development of new prognostic indicators and treatment strategies for oral squamous cell carcinoma. In this review, we summarize how changes in the extracellular matrix contribute to oral cancer development. ยฉ 2006 Wiley Periodicals, Inc. Head Neck, 2006

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