Direct injection of plasmid DNA into the
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D. Sawamura; R. Abe; M. Goto; M. Akiyama; H. Hemmi; S. Akira; H. Shimizu
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Article
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2005
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John Wiley and Sons
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English
⚖ 389 KB
## Abstract ## Background Direct injection of naked DNA into skin can be efficiently used to transfer genes into keratinocytes __in vivo__. However, bacterial DNA is known to be a potent stimulus for vertebrate immune cells and immune systems. Towards the clinical use of this method, this study ex