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The extent of the uptake of plasmid into the skin determines the immune responses induced by a DNA vaccine applied topically onto the skin

✍ Scribed by Zhen Yu; Woon-Gye Chung; Brian R. Sloat; Christiane V. Löhr; Richard Weiss; B. Leticia Rodriguez; Xinran Li; Zhengrong Cui


Book ID
118111464
Publisher
Pharmaceutical Press
Year
2011
Tongue
English
Weight
501 KB
Volume
63
Category
Article
ISSN
2042-7158

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Direct injection of plasmid DNA into the
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## Abstract ## Background Direct injection of naked DNA into skin can be efficiently used to transfer genes into keratinocytes __in vivo__. However, bacterial DNA is known to be a potent stimulus for vertebrate immune cells and immune systems. Towards the clinical use of this method, this study ex