Abstract
Introduction
The purpose of the present study was to detect the presence of BASCβlike stem cellβrelated indicators, such as clara cell secretory protein (CCSP), Octamerβ4 (OCT4) and Bmiβ1, and evaluate their implications in the prognosis of patients with lung adenocarcinoma.
Methods
Specimens of 134 cases of lung adenocarcinoma were collected after radical surgery from January 1999 to June 2004.
Results
One hundred and twentyβsix cases showed cells that were positive for CCSP, 99 cases positive for OCT4, 91 cases simultaneous expression of CCSP and OCT4 and 74 cases positive for Bmiβ1. Bmiβ1 was significantly higher in patients at stage III compared to patients at stages I and II. The pattern of survival curves showed that Bmiβ1 was a significant prognostic factor of poor overall survival in lung adenocarcinoma patients (Pβ=β0.0000), and the patients with OCT4^+^ expression showed a greater increase in mortality than OCT4^β^ patients (Pβ=β0.0103). The results of univariate and multivariate Cox analysis revealed that the pathological stages of tumor node metastases (Pβ=β0.037), OCT4 (Pβ=β0.046) and Bmiβ1 expression (Pβ=β0.001) were independent prognostic factors.
Conclusions
OCT4 and Bmiβ1 may be good biomarkers to predict the prognosis of patients with completely resected lung adenocarcinoma. J. Surg. Oncol. 2010;102:856β862. Β© 2010 WileyβLiss, Inc.