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The expression of p16INK4a, the product of a tumor suppressor gene for melanoma, is upregulated in human melanocytes by UVB irradiation

โœ Scribed by Michael Piepkorn


Book ID
117844462
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
73 KB
Volume
42
Category
Article
ISSN
1097-6787

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Homozygous deletion of the p16INK4a and
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Chromosome 9p21 is frequently deleted in malignant melanoma, and one familial malignant melanoma gene has been linked to 9p21-22. Recently, the cyclin D-dependent kinase inhibitors (CDKIs) p16INK4a and p15INK4b have been localized within chromosome 9p21, and the presence of p16INK4a point mutations