The expression of efflux and uptake transporters are regulated by statins in Caco-2 and HepG2 cells
β Scribed by Rodrigues, Alice Cristina; Curi, Rui; Genvigir, Fabiana Dalla Vecchia; Hirata, Mario Hiroyuki; Hirata, Rosario Dominguez Crespo
- Book ID
- 109832521
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- Chinese
- Weight
- 491 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1671-4083
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## Abstract Ceftibuten uptake from the apical and basolateral side of Cacoβ2 cells grown on transwells was studied. Uptake into the cells showed concentration dependent saturation. The apical transporter(s) showed a higher capacity and lower affinity for ceftibuten than the basolateral transporter(
To explain the increased plasma mitochondrial aspartate aminotransferase (mAspAT) observed in alcoholics, we cultured HepG2 hepatoma cells in ethanol. Acute (24 hour) exposure to 0, 20, 40, or 80 mmol/L ethanol produced a dose-dependent (r = .98) increase in mAspAT messenger RNA (mRNA) of < or = thi