As a first step towards elucidating the role that pro-protein convertases play in the growth regulation of breast cancer, we studied the gene expression of 6 known human convertase members (PC1/PC3, PC2, furin/PACE, PACE4, PC5/PC6 and PC7/LPC) in human breast cancer tumors and cell lines. PC1, furin
The expression of CDK4 gene in human breast cancer
β Scribed by Weiqun Xiao
- Publisher
- Chinese Anti-Cancer Association
- Year
- 1997
- Tongue
- English
- Weight
- 271 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1000-9604
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Maspin is a tumor suppressor whose expression is lost in many advanced breast cancers. Maspin has been shown to inhibit cell motility, invasion and metastasis; however, its precise role in normal mammary epithelium remains to be elucidated. Although expression of maspin mRNA is low or absent in most
Abnormal expression of homeobox genes may lead to the development of leukemias, lymphomas, and solid tumors. Expression of homeobox genes in mammary glands, however, has not been studied actively until recently. We have examined the expression of POU homeobox genes in human breast cancer cell lines
## Abstract __LAFβ4__, which encodes a nuclear protein with transactivation potential, is fused to the __MLL__ gene in acute lymphoblastic leukemia (ALL). We identified __LAFβ4__ as a gene that is transcriptionally deregulated in breast tumors and thus may have a pathological role in mammary tumori
## Abstract CDK9 associates with Tβtype cyclins and positively regulates transcriptional elongation by phosphorylating RNA polymerase II (RNAPII) and negative elongation factors. However, it is unclear whether CDK9 is required for transcription of most genes by RNAPII or alternatively plays a role