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The expression of CD44 adhesion molecules on seminoma cells: A new marker for early detection of the tumor

✍ Scribed by Faruk Hadziselimovic; Bruno Herzog; Lyman R. Emmons

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 117 KB
Volume: 77
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19960201)77:3<429::aid-cncr1>3.0.co;2-f

No coin nor oath required. For personal study only.

✦ Synopsis

he incidence of seminoma in Stage I and Stage I1 was assessed in T a large population. A testicular biopsy was obtained from infertile males and from cryptorchid boys who had undergone a corrective surgical procedure. In no patient was a tumor suspected. The tissue was embedded in Epon and semithin sections were analyzed histochemically with a light microscope. A total of 4746 biopsies were analyzed by the same investigator. The seminomatous tumor was confirmed by two methods: its typical histologic ultrastructural morphology,' and with immunohistochemical techniques employing a specific antiseminoma monoclonal antibody [YLEM:CVA512] .2 All together, 9 seminomas were found in 4084 patients. One of these patients subsequently developed seminomas in both testes.

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