The expression of a specific 2-deoxyglucose-6P phosphatase prevents catabolite repression mediated by 2-deoxyglucose in yeast

✍ Scribed by F. Randez-Gil; J. A. Prieto; P. Sanz

• Book ID: 104719414
• Publisher: Springer-Verlag
• Year: 1995
• Tongue: English
• Weight: 813 KB
• Volume: 28
• Category: Article
• ISSN: 0172-8083
• DOI: 10.1007/bf00315774

✦ Synopsis

2-deoxyglucose (2-DOG), a non-metabolize analogue of glucose, is taken up by yeast using the same transporter(s) as glucose and is phosphorylated by hexokinases producing 2-deoxyglucose-6-P. We found that in DOGR yeasts, 2-DOG was not able to trigger glucose repression, even at concentrations of 0.5%. This result suggests that the specific 2-DOG-6P phosphatase, the enzyme responsible for the DOGR phenotype, may be involved in inhibiting the process of catabolite repression mediated by 2-DOG.